-
Advantages of Central Screening
Global Screening When Genesis Limited began its multicenter trials, the model was straightforward: engage physician groups in the countries where interested patients were already located. Rather than requiring subjects to travel blind into an unfamiliar program, Genesis ensured that local physicians clinically examined every candidate before they entered the trial.…
-
Benzodiazepine GABAergic excitation: recovery strategies
The GABA-benzodiazepine receptor complex inhibits neurotransmission, thereby producing a calming effect to suppress symptoms. For the GABA-benzodiazepine receptor complex to be established, GABAergic excitation and thereby the production of GABA is a prerequisite. GABA is an inhibitory neurotransmitter and has a parallel inhibitory role in the immune system. The immune…
-
The journey from Neuro-inflammation to Endocrine
Physical, environmental, or direct chemical (drug) induced brain inflammation triggers general immune action toward endothelial linings of blood vessels in the brain. This process causes damage to the vessel wall and fibrinoid necrosis, narrowing the lumen due to thickening or total occlusion due to thrombosis resulting in tissue ischemia and…
-
Cryopreserved (frozen) cells: Should you be concerned?
Cryopreservation is a means to slow down and bring to a halt, metabolic functions within a living organism and prevent the decomposition of various organic compounds that make up that living organism. This is achieved by safely transitioning the organism into a sub-zero frozen state. The lower the temperature, the…